Keeping your gut clean to prevent chronic diseases. – By Dr harold Gunatillake
Website: www.Doctorharold.com
How does Gut bacteria (microbiome) control your health?
Having a diverse range of “good” bacteria are the cornerstone of a healthy gut.
In fact, having a thriving, varied gut microbiome is important for overall health — not just gut health.
Just like taking precautionary steps to prevent heart disease, liver, and kidney disease, among others, you need to take steps to keep your gut clean for the benefit of your daily life.
If you have any gut disorder, your brain also will not function normally because of the gut-brain connection. In fact, the gut is also referred to as the second brain.
The earliest symptoms of gut disorders are abdominal discomfort, colicky pains, nausea, and vomiting if it involved the upper intestines, or change of bowel habits if the large gut is involved, such as constipation or lose motions.
The intestine is essential for life, and it is continuously exposed to foreign antigens, food poisoning, and other environmental agents. Therefore, it comprises the largest compartment of the immune system, with substantial amounts of organized lymphoid tissue and large populations of scattered innate and adaptive effector cells.
The intestines have built up their own immune system to protect them from outside influences.
“Seventy percent of the immune system is located in the gut,” says David Heber, MD, PhD, professor
emeritus of medicine at UCLA Health. “Nutrition is a key modulator of immune function.”
This means that more than two-thirds of your body’s immune cells reside in your gut. The tissue where the immune cells live is called the gut-associated lymphoid tissue—or
“GALT”—for short.
The central part of the villus comprises the lamina propria, where most intestinal immune cells are found, whereas intraepithelial lymphocytes (IELs) are found lying between epithelial cells.
The beneficial microbes in your large gut control this immune system. The beneficial gut microbes do this by ordering specialized immune cells to produce potent antiviral proteins that ultimately eliminate viral infections. And the body of a person lacking these beneficial gut bacteria won’t have as strong an immune response to invading viruses. Though not all disease begins in the gut, many chronic metabolic conditions are hypothesized to be caused or influenced by chronic gut inflammation.
By improving the gut microbes, you could enhance overall health. Such support comprises taking probiotics and eating fermented foods. …Eat prebiotic fibre. …Eat less sugar and sweeteners. …Reduce stress. …Avoid taking antibiotics unnecessarily. …Exercise regularly. … Get enough sleep.
Many parts of modern life can affect your gut microbiome, including high-stress levels. too little sleep. eating a Western diet high in processed and high-sugar foods.
Signs of an Unhealthy Gut are -Gas, Bloating, and Other Stomach Issues. …Unintentional Weight Fluctuations. … Skin Issues. …Moodiness, Irritability, and Trouble With Concentration. …Fatigue or Insomnia. …Sugar Cravings.
Let’s now talk about the inflammatory bowel diseases caused by the weakening of your gut immune system.
Inflammatory bowel disease (IBD) refers to two different chronic conditions or diseases that may be related: Crohn’s disease and ulcerative colitis. Both diseases consist of inflammation of the wall of the bowel or intestines – hence the name – leading to a bowel that is inflamed, and swollen and that develops ulcers. The inflammation and its consequences are different in Crohn’s disease and ulcerative colitis. The inflammation results in various degrees of abdominal discomfort, diarrhea, and intestinal bleeding. Both diseases can result in serious digestive problems.
In Crohn’s disease, inflammation involves the entire wall of the bowel, even the deeper portions. It may involve any part of the digestive tract from the mouth to the colon, rectum, and anus, although the small
intestine, particularly the ileum, is the most commonly involved organ with the colon the next most commonly involved organ. One of the characteristics of Crohn’s disease is that involvement of the bowel may be discontinuous, that is, several areas may be inflamed but intervening segments may be normal.
What is the difference Crohn’s and Ulcerative colitis?
Unlike Crohn’s disease, in ulcerative colitis, the inflammation involves only the superficial layers of the wall of the bowel, the innermost lining. Involvement is limited to the colon and rectum without skipped areas. Inflammation may be limited to the rectum (referred to as ulcerative proctitis), but usually is more extensive, extending variable distances to involve the sigmoid, descending, transverse, and ascending colon.
Although the symptoms of Crohn’s disease and ulcerative colitis are similar, they are not identical. Abdominal pain and diarrhea are common to both diseases as is loss of weight and fever. Ulcerative colitis tends to be associated with more bleeding due to the extensive erosion by inflammation of the blood vessels supplying the lining of the colon. On the other hand, symptoms of obstruction of the bowel (pain, nausea and vomiting, and abdominal distension) are more common in Crohn’s disease because the entire wall of the bowel is inflamed. The cause of IBD is unknown. What is known is that a combination of genetic and environmental factors results in ongoing inflammation localized mostly to the bowel that for some reason is not controlled. The continuing inflammation results in the local destruction of the bowel as well as manifestations outside of the bowel. Therefore, treatments are directed toward controlling inflammation.
IBD is sometimes confused with irritable bowel syndrome (IBS). The cause of IBS, as for IBD, is not known. The striking difference between the two diseases is that there is no identifiable inflammation in IBS. Some symptoms may be similar – abdominal pain, diarrhea – but the other symptoms and signs of IBD are not seen – bloody stools, fever, and weight loss. The cause of IBS is believed to be dysfunction of the intestinal muscles, nerves, and secretions and not inflammation. Signs of inflammation in the intestine, as well as symptoms outside of the abdomen, are not seen in IBS.
Most of this information is obtained from MedicineNet Inflammatory bowel disease (IBD) is a chronic An immune-mediated disease that affects the gastrointestinal tract. It is argued that environment, microbiome, and immune -mediated factors interact in a genetically susceptible host to trigger IBD.
Recently, there has been increased interest in the development, progression, and treatment of IBD because of our understanding of the microbiome. Researchers have proved that some factors can alter the microbiome and the pathogenesis of IBD. As a result, there has been increasing interest in the application of probiotics, prebiotics, antibiotics, fecal microbiota transplantation, and gene manipulation in treating IBD because of the possible curative effect of microbiome-modulating interventions.
Short-chain fatty acids (SCFA, mainly including butyrate, propionate, and acetate) are the primary products of the breakdown of non-digestible carbohydrates like fibre by gut bacteria. Among them, is butyrate, which is produced by Clostridium, enhances the the function of mucosal Treg cells and alleviates enteritis in mice.
The increase in butyrate can also promote the The proliferation of Treg cells exerts its protective
effect on the gut. Regulatory T cells (Tregs) are critical for tuning the intestinal immune response to self- and non-self-antigens in the intestine.
Its importance in intestinal homeostasis is illustrated by the onset of overt inflammation caused by a deficiency in Treg generation, function, or stability in the gut.
What are Treg cells?
Regulatory T cells (Tregs) are a specialized The subpopulation of T cells that act to suppress the immune response, thereby maintaining homeostasis and self-tolerance. It has been shown that Tregs are able to inhibit T cell proliferation and cytokine production and play a critical role in preventing autoimmunity.
The ultimate solution to prevent inflammatory bowel diseases lies in looking after the beneficial gut microbes by feeding them through nondigestible food particles and the production of short-chain fatty acids by the microbes.
I hope this video article was useful to keep your bowels from inflammatory diseases, and for now stay safe and goodbye.
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